Last year's Olympic 800-meter winner challenged rules that might end her career.
Some female runners with high testosterone levels must take medicine to lessen their levels, according to IAAF rules.
Many regarded the guidelines as a deliberate attack on Semenya, who is thought to have excessive testosterone.
The Court of Arbitration for Sport rejected the runner's challenge of the new rules on Wednesday.
Semenya's narrative is about sports regulatory bodies' efforts to create fair gender divides for athletes.
It also explores what occurs when an athlete, particularly a black one, defies gender norms.
“Certain bodies are never allowed to be female, are never allowed to be women, are never allowed to just be,” intersex activist,,,
and Intersex Justice Project co-founder Pidgeon Pagonis told Vox. Caster's faster than white girls and made them weep, I guess.
Semenya, a South African woman, has never shared her medical background.
Since her global debut a decade ago, the media, public, and athletes have speculated about her anatomy, misgendered her,,,
and suggested that she shouldn't run against other women.